Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TACR3

contributors: mct/npt - updated : 27-03-2019

HGNC name	tachykinin receptor 3
HGNC id	11528

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HHGTR

Susceptibility

to alcohol and cocaine dependence to nonobstructive azoospermia (NOA)

Variant & Polymorphism other	sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent (Foroud 2008)
	rs2765 SNP predicted the degree of impairment of learning and memory in the aged humans
	stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia

Candidate gene	for a critical central regulator of human gonadal function
	TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
Marker	important target to predict and improve learning and memory performance in the aged organism
Therapy target
	System Type Disorder Pubmed cancer digestive   signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction cancer angiogenesis   might be a potential novel target for the anti-angiogenesis therapy

ANIMAL & CELL MODELS