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FLASH GENE
Symbol TACR3 contributors: mct/npt - updated : 27-03-2019
HGNC name tachykinin receptor 3
HGNC id 11528
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text exclusively expressed in brain (Vassilatis 2003)
    basic FUNCTION
  • involved in regulation of human reproductive function (Guran 2009)
  • G-protein coupled receptor that is broadly distributed in the nervous system and exerts its diverse physiological actions through multiple signaling pathways
  • activation of the TACR3 appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression
  • TAC3/TACR3 have been implicated in the neuroendocrine control of GNRH1 release
  • TAC3 and its preferred tachykinin receptor 3 (TACR3) are prominently detected in the central nervous system, playing significant roles in physiological development and specifically in the human reproductive system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for the tachykinin neurokinin 3 (neurokinin B)
  • IRX6 can activate or repress transcription through Iroquois-binding sites found proximal to RCVRN, VSX1 and TACR3
  • peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HHGTR
    Susceptibility
  • to alcohol and cocaine dependence
  • to nonobstructive azoospermia (NOA)
    • Variant & Polymorphism other
  • sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent (Foroud 2008)
  • rs2765 SNP predicted the degree of impairment of learning and memory in the aged humans
  • stopgain mutation c.G992A (p.W331X) in TACR3 gene was identified in nonobstructive azoospermia
    • Candidate gene
  • for a critical central regulator of human gonadal function
  • TAC3/TACR3 system may provide a new avenue for the pharmacological manipulation of human fertility and the treatment of sex steroid–related diseases, such as cancers of the breast and prostate (Topaloglu 2009)
    • Marker
  • important target to predict and improve learning and memory performance in the aged organism
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestive 
    signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction
    cancerangiogenesis 
    might be a potential novel target for the anti-angiogenesis therapy
    ANIMAL & CELL MODELS