Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NES contributors: npt/mct/shn - updated : 01/11/2012
HGNC name nestin
HGNC id 7756
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to NES, Pan troglodytes
ortholog to Nes, Mus musculus
ortholog to nes, Danio rerio
ortholog to Nes, Rattus norvegicus
Homologene
FAMILY
  • intermediate filament family, type IV
    • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • playing a role in nervous system development and upon terminal neural differentiation, downregulated and replaced by neurofilaments
  • selective marker of the basal breast cancer phenotype, which displays features of mammary progenitors
  • having a function in cell motility
  • serves as a scaffold for Cdk5
  • required for acetylcholine-induced, Cdk5-dependent dispersion of acetylcholine-receptor clusters during neuromuscular junction development (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cdk5 and p35 kinase
  • cyclin-dependent kinase 5, CDK5
    • cell & other
    REGULATION
    Phosphorylated by cdc2 kinase
    Other cyclin-dependent kinase 5, CDK5 (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer cells from patients with lethal androgen-independent disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • nestin-deficient mice have a normal development of the central nervous system but show impaired motor coordination the number of acetylcholine receptor clusters, the nerve length, and the endplate bandwidth are significantly increased in neuromuscular junction area