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FLASH GENE

Symbol

PDIA6

contributors: mct - updated : 24-05-2019

HGNC name	protein disulfide isomerase-associated 6
HGNC id	30168

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

protein disulfide isomerase family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	localizes not only in the ER but also in mitochondria, although it remains unclear so far about its physiological significance(s) of its dual localization

basic FUNCTION	having substrate specificity with respect to chaperone activity
	mitochondrial PDIA6 may upregulate tricarboxylic acid cycle and possibly, other intramitochondrial metabolism
	surface expression of PDIA6 was shown to be dynamically regulated during sperm capacitation and, like that of previously characterized HSPA2-interacting proteins, this surface expression proved vulnerable to oxidative stress
	PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells
	PDIA6, COA1 have already been implicated in cancer progression
	may serve an important role in cancer cell growth

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	cooperation between HSPA5 and PDIA6, demonstrating that individual PDI family members recognise specific substrate proteins
	may act as a key reductase and target misfolded proinsulin to the ER-degradation pathway
	HSPA5 protects ADAM17 against PDIAA6 catalyzed inactivation
	PDIA6 interacted with MAP4K1 and inhibited its phosphorylation, ultimately inhibiting the JNK/JUN signaling pathway
	cell surface trafficking of P4HB, PDIA3, and PDIA6 is dependent on KDELR1, which travels in a dynamic manner to the cell surface

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         of PDIA6 significantly decreased the volume of giant cell tumors of bone (GCTB) tumoral     --over   in bladder cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a biomarker and therapeutic target for non-small cell lung cancer (NSCLC)patients
	alterations in PDIA3/PDIA6 expression levels may be involved in the breast carcinogenic process and should be further investigated as a marker of aggressiveness
Therapy target
	System Type Disorder Pubmed cancer lung   PDIA6 may serve as a therapeutic target for Non-small cell lung cancer (NSCLC) patients cancer brain   may be considered an attractive and potent target for the treatment of glioblastoma cancer urinary   could be targeted for the treatment of bladder cancer

ANIMAL & CELL MODELS