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FLASH GENE
Symbol GATAD2A contributors: mct - updated : 22-11-2013
HGNC name GATA zinc finger domain containing 2A
HGNC id 29989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one GATA-type zinc finger
  • a conserved region 2 that is required for histone tail interaction as well as for wild-type subnuclear distribution
    • HOMOLOGY
    interspecies homolog to murine Gatad2a (91.6pc)
    homolog to rattus Gatad2a (92.2pc)
    intraspecies paralog to GATAD2B
    Homologene
    FAMILY p66 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in methylation dependent transcriptional repression
  • is essential for development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of a complex containing MBD2, HDAC1 and/or HDAC2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding MBD3, P66BETA
  • GATAD2A, GATAD2B interact with MBD2 functionally and biochemically
  • a coiled-coil interaction between MBD2 and GATA2A proteins recruits the chromodomain helicase DNA-binding protein (CHD4) to the NuRD complex and is necessary for MBD2-mediated DNA methylation-dependent gene silencing
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS