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FLASH GENE

Symbol

GATAD2A

contributors: mct - updated : 22-11-2013

HGNC name	GATA zinc finger domain containing 2A
HGNC id	29989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017660 12 - 5689 NP_060130 - 633 - 2002 1218346

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument melanocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one GATA-type zinc finger
	a conserved region 2 that is required for histone tail interaction as well as for wild-type subnuclear distribution

HOMOLOGY

interspecies	homolog to murine Gatad2a (91.6pc)
	homolog to rattus Gatad2a (92.2pc)

intraspecies

paralog to GATAD2B

Homologene

FAMILY

p66 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	involved in methylation dependent transcriptional repression
	is essential for development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a complex containing MBD2, HDAC1 and/or HDAC2

INTERACTION

DNA

RNA

small molecule

protein	binding MBD3, P66BETA
	GATAD2A, GATAD2B interact with MBD2 functionally and biochemically
	a coiled-coil interaction between MBD2 and GATA2A proteins recruits the chromodomain helicase DNA-binding protein (CHD4) to the NuRD complex and is necessary for MBD2-mediated DNA methylation-dependent gene silencing

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS