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FLASH GENE

Symbol

FTMT

contributors: - updated : 08-03-2007

HGNC name	ferritin mitochondrial
HGNC id	17345

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain hindbrain medulla oblongata     Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	mitochondrial targeting motifs
	ferritin-like diiron domain

mono polymer

homomer , heptamer

HOMOLOGY

interspecies	homolog to chimpanzee FTMT (97,52 pc)
	homolog to murine Ftmt (77,54 pc)

intraspecies

homolog to FTH1

Homologene

FAMILY

ferritin family

CATEGORY

storage

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	storing iron in a soluble, nontoxic, readily available form
	composed of 24 chains, roughly spherical and containing a central cavity into which the polymeric ferric iron core is deposited

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism SNP	a G to T substitution adjacent to the Bbf binding site, in position -69 with a significantly reduced transcriptional activity of this allele compared to that of the wild type promoter

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS