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FLASH GENE
Symbol FTMT contributors: - updated : 08-03-2007
HGNC name ferritin mitochondrial
HGNC id 17345
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     1 Exon(s)
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • a binding site for SP1 transcription factor
  • a binding site for BBF protein complex
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondrial targeting motifs
  • ferritin-like diiron domain
    • mono polymer homomer , heptamer
    HOMOLOGY
    interspecies homolog to chimpanzee FTMT (97,52 pc)
    homolog to murine Ftmt (77,54 pc)
    intraspecies homolog to FTH1
    Homologene
    FAMILY ferritin family
    CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • storing iron in a soluble, nontoxic, readily available form
  • composed of 24 chains, roughly spherical and containing a central cavity into which the polymeric ferric iron core is deposited
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP a G to T substitution adjacent to the Bbf binding site, in position -69 with a significantly reduced transcriptional activity of this allele compared to that of the wild type promoter
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS