Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FBXO44 contributors: mct - updated : 28-06-2014
HGNC name F-box protein 44
HGNC id 24847
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one F-box domain
HOMOLOGY
intraspecies homolog to FBXO2
Homologene
FAMILY NFB42 (neural F Box 42 kDa) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • recognizing and binding to some phosphorylated proteins and promoting their ubiquitination and degradation
  • although the AAs that are necessary for binding to oligosaccharides are conserved between FBXO2 and FBXO44, FBXO44 does not bind glycoproteins
  • is an important protein that influences BRCA1 protein level
  • its expression pattern in breast carcinomas suggests that SCF(FBXO44)-mediated BRCA1 degradation might contribute to sporadic breast tumor development
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS