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FLASH GENE
Symbol FBXO44 contributors: mct - updated : 28-06-2014
HGNC name F-box protein 44
HGNC id 24847
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver   lowly
Lymphoid/Immunespleen   lowly
Nervousbrain   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one F-box domain
HOMOLOGY
intraspecies homolog to FBXO2
Homologene
FAMILY NFB42 (neural F Box 42 kDa) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • recognizing and binding to some phosphorylated proteins and promoting their ubiquitination and degradation
  • although the AAs that are necessary for binding to oligosaccharides are conserved between FBXO2 and FBXO44, FBXO44 does not bind glycoproteins
  • is an important protein that influences BRCA1 protein level
  • its expression pattern in breast carcinomas suggests that SCF(FBXO44)-mediated BRCA1 degradation might contribute to sporadic breast tumor development
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS