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FLASH GENE
Symbol FBXO44 contributors: mct - updated : 28-06-2014
HGNC name F-box protein 44
HGNC id 24847
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text arranged in tandem with FBXO2, FBXO6
STRUCTURE 8.95 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2948 - 255 - 2002 12383498
FBXO44 I1
5 - 2934 - 224 - 2002 12383498
  • FBXO44 I2
    • 7 - 3320 - 255 - 2002 12383498
    5 - 2823 - 224 - 2002 12383498
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   lowly
    Lymphoid/Immunespleen   lowly
    Nervousbrain   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		one F-box domain
    HOMOLOGY
    intraspecies homolog to FBXO2
    Homologene
    FAMILY NFB42 (neural F Box 42 kDa) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • recognizing and binding to some phosphorylated proteins and promoting their ubiquitination and degradation
  • although the AAs that are necessary for binding to oligosaccharides are conserved between FBXO2 and FBXO44, FBXO44 does not bind glycoproteins
  • is an important protein that influences BRCA1 protein level
  • its expression pattern in breast carcinomas suggests that SCF(FBXO44)-mediated BRCA1 degradation might contribute to sporadic breast tumor development
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS