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FLASH GENE
Symbol EXOSC8 contributors: mct - updated : 07-06-2018
HGNC name exosome component 8
HGNC id 17035
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine EXOSC8
homolog to rattus LOC295050
homolog to yeast Rrp43
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
basic FUNCTION
  • have 3'->5' exoribonuclease activity
  • processes the 3' terminus of precursor tRNA
  • required for rapid degradation of ARE-containing RNA
  • is an essential protein of the exosome core
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component exosome C RNase complex
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • interacts with RPP14
  • GATA1/FOXO3 repressed expression of EXOSC8, a pivotal component of the exosome complex, which mediates RNA surveillance and epigenetic regulation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH1C
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    downregulating EXOSC8, or additional exosome complex components, in primary erythroid precursor cells induced erythroid cell maturation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS