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FLASH GENE
Symbol EXOSC8 contributors: - updated : 14-10-2004
HGNC name exosome component 8
HGNC id 17035
Location 13q13.1      Physical location : 37.574.677 - 37.583.749
Synonym name Opa-interacting protein 2
Synonym symbol(s) p9, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine EXOSC8
homolog to rattus LOC295050
homolog to yeast Rrp43
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • have 3'->5' exoribonuclease activity
  • processes the 3' terminus of precursor tRNA
  • required for rapid degradation of ARE-containing RNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component exosome C RNase complex
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein interacts with RPP14
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS