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FLASH GENE

Symbol

RAB11FIP4

contributors: mct - updated : 23-09-2014

HGNC name	RAB11 family interacting protein 4 (class II)
HGNC id	30267

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	146.59 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032932 15 - 8665 NP_116321 71.8 637 - 2002 12470645

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Lymphoid/Immune lymph node         Reproductive female system ovary         male system testis       Visual eye retina     highly Mus musculus Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an EF-hand calcium-binding domain

mono polymer

homomer , heteromer , oligo

HOMOLOGY

interspecies	homolog to rattus Rab11fip4 (93.4 pc)
	homolog to murine Rab11fip4 (93.2 pc)

Homologene

FAMILY

Rab11-FIP family of Rab11 interacting proteins

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
text	recycling endosome membrane

basic FUNCTION	acting in the endosomal trafficking
	likely RAB11FIP4 serves as a RAB11A effector in a RAB11A mediated function other than transferrin recycling
	RAB11FIP3, RAB11FIP4 are involved in the transport of endosomally derived membrane to the cleavage furrow during cytokinesis
	involvement potential of a novel RAB11-independent mechanism for RAB11FIP4 action in the regulation of retinal development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	homooligomer
	forming an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to RAB25
	interacting with RAB11A that has been activated by GTP binding
	interacts with RAB11A in a GTP-dependent manner and its C-terminal region allows the protein to self-interact and interact with RAB11FIP5, RAB11FIP2, and RAB11FIP3
	ECM29 binding VPS11, RAB11FIP4, and rabaptin
	TSG101 is a novel RAB11FIP4-binding protein, which we find can also bind RAB11FIP3

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS