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FLASH GENE
Symbol RAB11FIP4 contributors: mct - updated : 23-09-2014
HGNC name RAB11 family interacting protein 4 (class II)
HGNC id 30267
Location 17q11.2      Physical location : 29.718.641 - 29.865.232
Synonym name
  • FIP4-Rab11
  • arfophilin-2
    • Synonym symbol(s) RAB11-FIP4, KIAA1821, FLJ00131, MGC11316, MGC126566
    DNA
    TYPE functioning gene
    STRUCTURE 146.59 kb     15 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 8665 71.8 637 - 2002 12470645
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Lymphoid/Immunelymph node    
    Reproductivefemale systemovary   
     male systemtestis   
    Visualeyeretina  highly Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an EF-hand calcium-binding domain
    • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to rattus Rab11fip4 (93.4 pc)
    homolog to murine Rab11fip4 (93.2 pc)
    Homologene
    FAMILY Rab11-FIP family of Rab11 interacting proteins
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text recycling endosome membrane
    basic FUNCTION
  • acting in the endosomal trafficking
  • likely RAB11FIP4 serves as a RAB11A effector in a RAB11A mediated function other than transferrin recycling
  • RAB11FIP3, RAB11FIP4 are involved in the transport of endosomally derived membrane to the cleavage furrow during cytokinesis
  • involvement potential of a novel RAB11-independent mechanism for RAB11FIP4 action in the regulation of retinal development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • homooligomer
  • forming an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to RAB25
  • interacting with RAB11A that has been activated by GTP binding
  • interacts with RAB11A in a GTP-dependent manner and its C-terminal region allows the protein to self-interact and interact with RAB11FIP5, RAB11FIP2, and RAB11FIP3
  • ECM29 binding VPS11, RAB11FIP4, and rabaptin
  • TSG101 is a novel RAB11FIP4-binding protein, which we find can also bind RAB11FIP3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS