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FLASH GENE

Symbol

SLC25A26

contributors: mct - updated : 09-12-2015

HGNC name	solute carrier family 25, member 26
HGNC id	20661

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SAMD S-adenosylmethionine deficiency
Location	3p14.1      Physical location : 66.119.284 - 66.429.348
Synonym name	S-adenosylmethionine carrier protein
Synonym symbol(s)	SAMC, FLJ77340, DKFZp434E079

DNA

TYPE	functioning gene
STRUCTURE	246.41 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_173471 8 - 2686 NP_775742 29.3 274 - 2004 14674884 NM_001164796 9 - 2154 NP_001158268 - 186 - 2004 14674884

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Endocrine neuroendocrine pituitary     moderately Hearing/Equilibrium ear       highly Lymphoid/Immune tonsils       moderately Nervous brain       lowly Reproductive female system placenta     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   moderately

cell lineage
cell lines
fluid/secretion	highly in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four ef-hand calcium-binding domains
	three solcar repeats

HOMOLOGY

interspecies	homolog to rattus Slc25a26 (88.1 pc)
	homolog to murine Slc25a26 (88.3 pc)

Homologene

FAMILY

mitochondrial carrier family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
text	multi-pass membrane protein
	transported into the mitochondria where it is converted into S-adenosylhomocysteine in methylation reactions of DNA, RNA and proteins

basic FUNCTION	mediatings the transport of S-adenosylmethionine (SAM) into the mitochondria
	acting as a calcium-dependent mitochondrial aspartate and glutamate carrier
	may have a function in the urea cycle
	physiological role of SAMC is probably to exchange cytosolic SAM for mitochondrial S-adenosylhomocysteine
	synthesized by methionine adenosyltransferase from methionine and ATP in the cytoplasm and subsequently distributed throughout the different cellular compartments, including mitochondria, where methylation is mostly required for nucleic-acid modifications and respiratory-chain function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

mitochondrial transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	ca2+

protein

mitochondrial SLC25A26 targets, ANT1 and ANT2, and the electron-transferring flavoprotein ETFB

cell & other

REGULATION

inhibited by

tannic acid and Bromocresol Purple

ASSOCIATED DISORDERS

corresponding disease(s)

SAMD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS