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FLASH GENE
Symbol KLHL40 contributors: mct - updated : 14-09-2013
HGNC name kelch-like family member 4
HGNC id 30372
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one btb/poz domain
  • five kelch repeat motifs
    • HOMOLOGY
    interspecies homolog to murine Kbtbd5
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein binding activity
  • crucial for myogenesis and skeletal-muscle maintenance
  • is more important for myogenesis than for muscle maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM8
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS