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FLASH GENE

Symbol

KLHL40

contributors: mct - updated : 14-09-2013

HGNC name	kelch-like family member 4
HGNC id	30372

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.93 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152393 6 - 2423 NP_689606 - 621 - 2013 23746549

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one btb/poz domain
	five kelch repeat motifs

HOMOLOGY

interspecies

homolog to murine Kbtbd5

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

basic FUNCTION	protein binding activity
	crucial for myogenesis and skeletal-muscle maintenance
	is more important for myogenesis than for muscle maintenance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NEM8

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS