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FLASH GENE
Symbol GRHL1 contributors: mct - updated : 21-09-2011
HGNC name grainyhead-like 1 (Drosophila)
HGNC id 17923
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to murine Grhl1 (94.5pc)
Homologene
FAMILY
  • grh/CP2 family
  • Grainyhead subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed
  • may be involved in epidermal differentiation
  • may function as a transcription factor during development
  • may play important roles in mammalian development
  • an important regulator of the DSG1 genes in the context of hair anchorage and epidermal differentiation
  • transcriptional factor that regulate the expression of the P450 side-chain cleavage enzyme (CYP11A1) in the human placenta (Henderson 2009)
  • cooperative roles of the GRHL genes in epidermal development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer but also forming heterodimers with GRHL2 and GRHL3
    • INTERACTION
    DNA binding the EN1 promoter
    RNA
    small molecule
    protein
  • interacting with sister of mammalian grainyhead (SOM)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • Grhl1-null mice show an initial delay in coat growth, and older mice exhibit hair loss as a result of poor anchoring of the hair shaft in the follicle
    • ANIMAL & CELL MODELS