Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NEXN contributors: mct - updated : 16-12-2009
HGNC name nexilin (F actin binding protein)
HGNC id 29557
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminally located actin-binding domains (ABD)
  • one IQ domain
  • one myosin-like globular head domain
  • a coiled-coil domain (CC)
  • a C-terminal immunoglobulin superfamily class
    • HOMOLOGY
    interspecies homolog to murine Nexn
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • F-actin-binding protein at cell-matrix adherens junctions
    • basic FUNCTION
  • may regulate the formations of stress fibers, focal adhesion and its signaling complex, and even participate in the signal transduction in focal adhesions
  • F-actin associated protein that mediates cell motility
  • Z-disk protein, playing an unique role in protecting Z-disks from mechanical trauma
  • crucial protein that functions to protect cardiac Z-discs from forces generated within the sarcomere
  • has a unique role in stabilizing cardiac Z-discs and is essential for maintaining Z-disc integrity against the extreme forces generated during muscle contraction
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • F-actin associated protein
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1CC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS