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FLASH GENE
Symbol NEXN contributors: mct - updated : 16-12-2009
HGNC name nexilin (F actin binding protein)
HGNC id 29557
Corresponding disease
CMD1CC cardiomyopathy, dilated or hypertrophic 1 CC
Location 1p31.1      Physical location : 78.354.199 - 78.409.576
Synonym name
  • nexilin
  • nelin
  • F-actin binding protein
  • Synonym symbol(s) NELIN, nexilin, MGC104234, MGC138865, MGC138866
    DNA
    TYPE functioning gene
    STRUCTURE 53.38 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3405 - 675 - 2009 19881492
    12 - 3213 - 611 - 2009 19881492
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Skin/Tegumentskinscalp    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminally located actin-binding domains (ABD)
  • one IQ domain
  • one myosin-like globular head domain
  • a coiled-coil domain (CC)
  • a C-terminal immunoglobulin superfamily class
  • HOMOLOGY
    interspecies homolog to murine Nexn
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • F-actin-binding protein at cell-matrix adherens junctions
  • basic FUNCTION
  • may regulate the formations of stress fibers, focal adhesion and its signaling complex, and even participate in the signal transduction in focal adhesions
  • F-actin associated protein that mediates cell motility
  • Z-disk protein, playing an unique role in protecting Z-disks from mechanical trauma
  • crucial protein that functions to protect cardiac Z-discs from forces generated within the sarcomere
  • has a unique role in stabilizing cardiac Z-discs and is essential for maintaining Z-disc integrity against the extreme forces generated during muscle contraction
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • F-actin associated protein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMD1CC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS