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FLASH GENE
Symbol XCR1 contributors: mct - updated : 08-01-2013
HGNC name chemokine (C motif) receptor 1
HGNC id 1625
Location 3p21.31      Physical location : 46.062.291 - 46.068.979
Synonym name chemokine (C motif) XC receptor 1
Synonym symbol(s) GPR5, CCXCR1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.69 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text
  • same protein encoded by all variants
    • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1373 38 333 - 1998 :9632725
    2 splicing 1251 38 333 - 1998 :9632725
  • lacking an exon in the 5prime UTR compared to variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth     Homo sapiens
    Lymphoid/Immunethymus   highly Homo sapiens
    Reproductivefemale systemplacenta  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier lining    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text
  • placenta
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
    • HOMOLOGY
    interspecies homolog to rattus Xcr1 (70.9 pc)
    homolog to murine Xcr1 (72.3 pc)
    intraspecies homolog to chemokine beta receptor 1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a receptor for chemokines SCYC1 and SCYC2
  • transducing a signal by increasing the intracellular calcium ions level
  • acting as a rhodopsin-like receptor
  • XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells
  • role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation byhuman dendritic cells
  • emerges as the first surface marker characterizing a dendritic cell lineage potentially in the human
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response
  • XCL1-XCR1 axis thus emerges as an integral component in the development of efficient cytotoxic immunity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • certain dendritic cells subsets should be chemotactic towards Natural killer or activated CD8(+) T cells through XCR1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of XCR1 expression in mononuclear cells from the rheumatoid joint, and detected XCR1 expression in infiltrating mononuclear cells in synovial tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS