| Symbol
| MST1R
| contributors: mct/pgu - updated : 01-02-2015
|
| HGNC name
| macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
|
| HGNC id
| 7381
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| gain of function
| |
in the invasive phenotype of colorectal carcinomas | | tumoral
|
|
|
| gain of function
| |
in lung carcinoma | | constitutional
|
|
| --over
|
| |
can inhibit cell proliferation and induce senescence | | tumoral
|
|
| --over
|
| |
in hypopharyngeal squamous cell carcinoma | | tumoral
|
|
| --over
|
|
in a significant number of breast cancer tissues as well as in many established breast cancer cell lines  | | tumoral
|
|
| --over
|
| |
frequently overexpressed and constitutively phosphorylated in a number of human malignancies | |
| Variant & Polymorphism
insertion/deletion
, other
| splicing variant of 160kDa cleaved into an alpha 40kDa chain a 125kDa beta chain resulting from a 109AA deletion of the extracellular domain, in colorectal carcinomas |
| 
|
Candidate gene
| Marker
| novel prognostic marker and therapeutic target for gastroesophageal cancer | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | brain | glioma/neuroblstoma | |
| malignant glioma could represent candidate targets for treatment with agents inhibiting MST1R activity | | cancer | hemopathy | | |
| may be a novel therapeutic target for EBV-associated lymphoproliferative diseases |
| | |
|
| conferring susceptibility to friend virus induced erythroleukemia in mice |