basic FUNCTION
| tyrosine phosphatase, non receptor, responding and participating in reorganization of membrane-cytoplasmic interactions |
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in association with PARG1, may function as a negative regulator of Rho signaling |
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plays a counteracting role in regulating TRIP6 function in lysophosphatidic acid (LPA)-induced cell migration |
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plays a wider role in modulating cell motility through dephosphorylation of other substrates involved in cell adhesion and migration |
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specifically dephosphorylates insulin receptor substrate-1 (IRS1), having a crucial role in IRS1 dephosphorylation |
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direct positive role of the putative tumor suppressor gene PTPN13 on apoptosis |
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IRF8-induced PTPN13 repression occurred in granulocyte/monocyte progenitor cells, and this activity increased during myeloid differentiation |
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PTPN13 is an IRF8 target gene |
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inhibits ERBB2 activity by dephosphorylating the signal domain of ERBB2 and plays a role in attenuating invasiveness and metastasis of ERBB2 overactive tumors |
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important regulatory element of breast tumor aggressiveness and sensitivity to treatments such as antiestrogens and antiaromatase |