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FLASH GENE

Symbol

REG1A

contributors: mct/npt - updated : 20-11-2024

HGNC name	regenerating islet-derived 1 alpha
HGNC id	9951

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   highly mRNA expression in brains with Alzheimer's disease (de la Monte 1990) constitutional     --other   expressed in Barrett's esophagus (Chinuki 2008) constitutional     --over   during the very early stages of Alzheimer disease, and REG1A deposits were detected in the brain of patients with Alzheimer disease constitutional     --over   in regenerating pancreatic islets constitutional     --over   in type 1 diabetes patients and type 2 diabetic subjects with anti-REG1A antibodies in 47p100 of type 1 diabetes constitutional     --over   substantially increased in the inflamed colorectal tissues of inflammatory bowel disease (IBD) patients tumoral     --low   in Gastric Cancer tumoral     --over   in bladder cancer tissues compared with adjacent normal samples, associated with shorter recurrence times and poor survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	REG1A protein levels can be used as a biomarker for the diagnosis and monitoring of Celiac disease
	can be used as a marker of recurrence and prognosis in bladder cancer
	is a potential biomarker for ER stressed pancreatic beta cells, as in the case of Wolfram syndrome
	REG1A levels could be a novel biomarker for assessment of renal function in pregnant women
	potential use of REG1A as a sepsis biomarker
Therapy target
	System Type Disorder Pubmed cancer skin   epigenetic regulation of the REG1A promoter region may offer a potential therapeutic approach to improve chemotherapy for metastatic melanoma patients immunology inflammatory   restoration of normal physiological REG1α expression may contribute to rheumatoid arthritis amelioration neurosensorial visual retina potential application in the prevention and treatment of retinal vision loss immunology inflammatory   REG1A controlled by IL6/IL22-JAK-STAT3 signaling may provide a promising therapeutic target for patients with IBD cancer digestive stomach may serve as a promising therapeutic strategy for GC cancer urinary   REG1A targeting in bladder cancer patients represents a promising therapeutic strategy

ANIMAL & CELL MODELS

Reg1 is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration