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FLASH GENE
Symbol GTF2H5 contributors: mct - updated : 26-01-2022
HGNC name general transcription factor IIH, polypeptide 5
HGNC id 21157
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gtf2h5
intraspecies homolog to yeast TFB5
Homologene
FAMILY TFB5 family
CATEGORY transcription factor , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • plays a role in nucleotide excision repair
  • regulating expression of TF2H
  • involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
  • appeared important for the stabilization of the entire TFIIH complex
  • essential for Nucleotide excision repair (NER), appeared to be required also for embryonic development, indicative for the big impact this small protein has on basal biological processes
  • is a multisubunit complex essential for both transcription by RNA polymerase II and nucleotide excision repair
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of polymerase II preinitiation complexes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the GTF2H4 and the GTF2H4-GTF2H5-GFP product is incorporated into TFIIH
  • recruits XPA through its first 15 amino acids
  • is an upstream regulator of TP53-mediated apoptosis and acts as an oncogene, suggesting its value as a potential molecular target for the diagnosis and treatment of glioma
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TTDA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    inhibited apoptosis of glioma cells and promoted cell growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS