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FLASH GENE

Symbol

GTF2H5

contributors: mct - updated : 26-01-2022

HGNC name	general transcription factor IIH, polypeptide 5
HGNC id	21157

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_207118 2 - 7503 NP_997001 8 71 - 2007 17350038

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately   vessel       lowly Endocrine adrenal gland       highly Reproductive male system prostate     highly

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Gtf2h5

intraspecies

homolog to yeast TFB5

Homologene

FAMILY

TFB5 family

CATEGORY

transcription factor , antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	plays a role in nucleotide excision repair
	regulating expression of TF2H
	involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
	appeared important for the stabilization of the entire TFIIH complex
	essential for Nucleotide excision repair (NER), appeared to be required also for embryonic development, indicative for the big impact this small protein has on basal biological processes
	is a multisubunit complex essential for both transcription by RNA polymerase II and nucleotide excision repair

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of polymerase II preinitiation complexes

INTERACTION

DNA

RNA

small molecule

protein	interacts with the GTF2H4 and the GTF2H4-GTF2H5-GFP product is incorporated into TFIIH
	recruits XPA through its first 15 amino acids
	is an upstream regulator of TP53-mediated apoptosis and acts as an oncogene, suggesting its value as a potential molecular target for the diagnosis and treatment of glioma

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TTDA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   inhibited apoptosis of glioma cells and promoted cell growth

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS