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FLASH GENE
Symbol GP5 contributors: - updated : 10-01-2007
HGNC name glycoprotein V (platelet)
HGNC id 4443
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal peptide
  • one extracellular leucine-rich domain (14 LRRs)
  • a hydrophobic transmembrane domain near the C terminus
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Gp5
    Homologene
    FAMILY leucine-rich glycoprotein family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • mediating Von Willebrand factor -dependent platelets adhesion to blood vessels
  • GP1B complex involved in adhesion of a damaged vessel wall to the extra cellular matrix
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the GP1B (von Willebrand receptor) where it is non covalently bound to the GP1B complex
  • part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein cleaved upon agonist-induced platelet activation and ADAM17 is the major enzyme mediating this process
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS