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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CCR1

contributors: mct - updated : 06-05-2020

HGNC name	chemokine (C-C motif) receptor 1
HGNC id	1602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Alzheimer's disease (early and specific marker) tumoral     --over   in invasive intestinal tumors tumoral     --over   correlated with the aggressive phenotype of the non-small cell lung cancer cell constitutional     --low   is associated with risk of Behçet disease (BD) constitutional     --over   expression of CCR1 and CCR2 is up-regulated in peripheral blood B cells upon EBV infection constitutional     --low   in narcolepsy constitutional     --over   in endometrial cells was significantly higher in women with adenomyosis compared to those without adenomyosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   might be a new target for non-small cell lung cancer therapy allergy     potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease osteoarticular bone ostéoporosis target of new therapeutic strategies for the treatment of patients with bone destruction diseases and osteoporosis cancer digestive liver blockade of CCL15-CCR1 axis in hepatocellular carcinoma (HCC) could be an effective anticancer therapy immunology inflammatory   CCR1 and its ligands may be a potential target for treating inflammatory diseases involving upregulation of cell adhesion molecules cancer digestive liver CCR1 is a potential therapeutic target for controlling metastasis in HCC patients with high SPP1 cancer digestive liver may be a potential molecular target in hepatocellular carcinoma therapy miscelleaneous pain   at the inflammatory site, CCR1 antagonism may provide a dual benefit by restricting leukocyte trafficking and reducing pain

ANIMAL & CELL MODELS

CCR1-deficient mice have fewer and thinner trabecular bones and low mineral bone density in cancellous bones