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FLASH GENE

Symbol

CCR1

contributors: mct - updated : 06-05-2020

HGNC name	chemokine (C-C motif) receptor 1
HGNC id	1602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001295 2 - 2690 NP_001286 - 355 - 2018 29285854

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Reproductive female system placenta     highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet Skeleton osteoblast Homo sapiens Skeleton osteoclast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

interspecies

homolog to cmkbr1

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	playing a role in host protection from inflammatory response, and susceptibility to virus and parasite
	having an important regulatory role in colon cancer progression
	in collaboration with CCL23, mediates endothelial cell migration
	CCL3/CCR1 axis may have a role in the spread of tumoral cells to the lymph nodes and also in the local host defense against the tumor
	play an important role in the host response to pathogens
	plays a critical role in the recruitment of leukocytes to the site of inflammation
	regulates inflammatory cell infiltration after renal ischemia-reperfusion injury
	role for a role for CCR1 signaling in the pathogenesis of hematolymphoid neoplasia
	CCR1 signaling mediated by its ligands (CCL4, CCL5, CCL 9, and CCL11) plays an essential role in mineralized nodule formation
	plays a critical role on osteoblast-osteoclast communication through the regulation of the TNFRSF11A and TNFSF11A expression
	its activation may potentially play a role in the photoreceptor apoptosis
	chemokine signaling via CCR1 may be involved in regulation of stemness of adipose tissue derived stromal cells (ADSCs)
	CCR1 exhibits significant constitutive activity leading to a variety of cellular responses, and its expression is sufficient to induce inhibition of cAMP formation, increased F-actin content, and basal migration of leukocytes
	CCR1 mediates trafficking of leukocytes to sites of inflammation
	CCR1 functions likely to significantly modulate pain by controlling neutrophil trafficking to the inflammatory site and having an unexpected role on non-hematopoietic cells
	potential role of CCR1, CCR3 genes in narcolepsy
	expression levels of CCR1, CCR5 were higher in bone marrow mast cell progenitors (MCp) than in the peripheral blood, suggesting that CCR1 and CCR5 may mediate retention in the bone marrow

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	high affinity binding for monocyte chemoattractant protein 3
	interaction between CCR1 and its ligands, CCL5 and CCL9, could be involved in osteoclast differentiation
	CCL15 is a CC chemokine that binds to the CCR1 and CCR3
	macrophages confer survival signals via CCR1-dependent translational MCL1 induction in chronic lymphocytic leukemia

cell & other

REGULATION

induced by

SPP1 (CCR1 and CXCR6 are the most upregulated chemokine receptors induced by SPP1) (

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Alzheimer's disease (early and specific marker) tumoral     --over   in invasive intestinal tumors tumoral     --over   correlated with the aggressive phenotype of the non-small cell lung cancer cell constitutional     --low   is associated with risk of Behçet disease (BD) constitutional     --over   expression of CCR1 and CCR2 is up-regulated in peripheral blood B cells upon EBV infection constitutional     --low   in narcolepsy constitutional     --over   in endometrial cells was significantly higher in women with adenomyosis compared to those without adenomyosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   might be a new target for non-small cell lung cancer therapy allergy     potential target for alleviating T-cell accumulation during exacerbation of asthmatic disease osteoarticular bone ostéoporosis target of new therapeutic strategies for the treatment of patients with bone destruction diseases and osteoporosis cancer digestive liver blockade of CCL15-CCR1 axis in hepatocellular carcinoma (HCC) could be an effective anticancer therapy immunology inflammatory   CCR1 and its ligands may be a potential target for treating inflammatory diseases involving upregulation of cell adhesion molecules cancer digestive liver CCR1 is a potential therapeutic target for controlling metastasis in HCC patients with high SPP1 cancer digestive liver may be a potential molecular target in hepatocellular carcinoma therapy miscelleaneous pain   at the inflammatory site, CCR1 antagonism may provide a dual benefit by restricting leukocyte trafficking and reducing pain

ANIMAL & CELL MODELS

CCR1-deficient mice have fewer and thinner trabecular bones and low mineral bone density in cancellous bones