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FLASH GENE
Symbol SLITRK5 contributors: SGE/npt - updated : 13-07-2010
HGNC name SLIT and NTRK-like family, member 5
HGNC id 20295
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (16 LRR (leucine-rich) repeats)
  • conjugated GlycoP , PhosphoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Slitrk5 (97.1pc)
    homolog to rattus Slitrk5 (97.1pc)
    Homologene
    FAMILY
  • SLITRK family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • having neurite-modulating activity (Aruga 2003)
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Slitrk5-null mice develop obsessive -compulsive behaviors, including excessive self grooming bordering on self mutilation and increased anxiety in the open maze test (Shmelkov 2010)