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FLASH GENE

Symbol

SLITRK5

contributors: SGE/npt - updated : 13-07-2010

HGNC name	SLIT and NTRK-like family, member 5
HGNC id	20295

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	7.00 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015567 3 - 4461 NP_056382 - 958 - Aruga (2003)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex   predominantly Homo sapiens   spinal cord       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

extracellular domains containing two clusters of LRRs (16 LRR (leucine-rich) repeats)

conjugated

GlycoP , PhosphoP

isoforms

Precursor

HOMOLOGY

interspecies	homolog to murine Slitrk5 (97.1pc)
	homolog to rattus Slitrk5 (97.1pc)

Homologene

FAMILY

SLITRK family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION	having neurite-modulating activity (Aruga 2003)
	implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
	SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
	SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Slitrk5-null mice develop obsessive -compulsive behaviors, including excessive self grooming bordering on self mutilation and increased anxiety in the open maze test (Shmelkov 2010)