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FLASH GENE
Symbol SLITRK3 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 3
HGNC id 23501
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide,
  • extracellular domains containing two clusters of LRRs (20 LRR (leucine-rich) repeats)
  • a cytoplasmic domain
  • a putative tyrosine phosphorylation site
    • HOMOLOGY
    interspecies homolog to rattus LOC310519
    ortholog to murine Slitrk3
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppressing neurite outgrowth
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • acting as a postsynaptic adhesion molecule that selectively regulates inhibitory synapse development via trans-interaction with axonal tyrosine phosphatase receptor PTPRD
  • control inhibitory synapse development selectively
  • acted exclusively at inhibitory synapses
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK3-PTPRD is an inhibitory-specific trans-synaptic organizing complex that is required for normal functional GABAergic synapse development
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    several types of brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Slitrk3-deficient mice exhibited decreases in inhibitory, but not excitatory, synapse number and function in hippocampal CA1 neurons and exhibited increased seizure susceptibility and spontaneous epileptiform activity