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FLASH GENE
Symbol SLITRK3 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 3
HGNC id 23501
Location 3q26.1      Physical location : 164.904.517 - 164.914.469
Synonym name slit and trk like gene 3
Synonym symbol(s) KIAA0848
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 4.28 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4281 - 977 - 2003 14557068
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex   Homo sapiens
cell lineage
cell lines astrocytomas, oligodendrogliomas, gliobastomas, gangliogliomas and primitive neuroectodermal tumors
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide,
  • extracellular domains containing two clusters of LRRs (20 LRR (leucine-rich) repeats)
  • a cytoplasmic domain
  • a putative tyrosine phosphorylation site
    • HOMOLOGY
    interspecies homolog to rattus LOC310519
    ortholog to murine Slitrk3
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppressing neurite outgrowth
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • acting as a postsynaptic adhesion molecule that selectively regulates inhibitory synapse development via trans-interaction with axonal tyrosine phosphatase receptor PTPRD
  • control inhibitory synapse development selectively
  • acted exclusively at inhibitory synapses
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK3-PTPRD is an inhibitory-specific trans-synaptic organizing complex that is required for normal functional GABAergic synapse development
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    several types of brain tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Slitrk3-deficient mice exhibited decreases in inhibitory, but not excitatory, synapse number and function in hippocampal CA1 neurons and exhibited increased seizure susceptibility and spontaneous epileptiform activity