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FLASH GENE
Symbol SLITRK1 contributors: mct/npt - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 1
HGNC id 20297
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (13 LRR (leucine-rich) repeats)
  • extracellular domain is secreted and this process is activated by protein kinase C and inhibited by an inhibitor of tumor necrosis factor-alpha converting enzyme (ADAM17)(Kajiwara 2009)
    • HOMOLOGY
    interspecies ortholog to murine Slitrk1
    Homologene
    FAMILY
  • SLITRK family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • enhancing neurite outgrowth and involved in neuronal differentiation
  • role of SLIRTK1 in developmental neuropsychiatric conditions (Kajiwara 2009)
  • contributes to the development of corticostriatal-thalamocortical circuits
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SLITRK1 and 14-3-3 proteins (Kajiwara 2009)
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GTS13
    Susceptibility
  • to Tourette syndrome (minor role ) (Zimprich 2008)
  • to obsessive-compulsive disorders (OCDs), and trichotillomania
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS