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FLASH GENE

Symbol

GPR133

contributors: mct - updated : 13-09-2011

HGNC name	G protein-coupled receptor 133
HGNC id	19893

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine neuroendocrine pituitary       Homo sapiens Reproductive female system ovary         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a GPS domain
	a PTX domain
	a seven transmembrane region (7tm_2)

HOMOLOGY

interspecies

homolog to murine Gpr133 (80.83 pc)

Homologene

FAMILY	G-protein coupled receptor 2 family, adhesion GPCR subfamily
	LN-TM7 subfamily

CATEGORY

adhesion , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be involved in neuropeptide signaling pathway
	novel gene associated with adult height
	adhesion G-protein-coupled receptor group V, with large genomic size, multiple introns, and a fascinating flora of functional domains
	activates the Gs protein/adenylyl cyclase pathway
	must functionally interact with a G protein to mediate intracellular inositol phosphate formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS