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FLASH GENE
Symbol KHDRBS2 contributors: mct/npt - updated : 28-05-2008
HGNC name KH domain containing, RNA binding, signal transduction associated 2
HGNC id 18114
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Lymphoid/Immunespleen    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KH domain, which is embedded in a larger conserved domain called the STAR domain
    • HOMOLOGY
    interspecies homolog to rattus Slm1
    homolog to murine Khdrbs2
    Homologene
    FAMILY
  • STAR protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be having nucleic acid binding activity
  • regulate actin organization, and is also necessary for normal sphingolipid metabolism, at least in part through regulation of the calcium/calmodulin-dependent phosphatase calcineurin, which binds directly to both proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA associated
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS