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FLASH GENE
Symbol NTNG2 contributors: mct - updated : 04-12-2019
HGNC name netrin G2
HGNC id 14288
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 22 laminin EGF-like domains
  • 5 laminin g-like domains
  • one laminin IV domain
  • one laminin n-terminal domain
  • the alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
    • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to NTNG1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • may be mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
  • plays a role in synapse formation and maintenance
  • both the GNG2 and the NTNG2 proteins show an affinity to the claustrum and related formations in the human brain
  • NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
  • pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties
  • membrane-anchored protein implicated in the molecular organization of neuronal circuitry and synaptic organization
  • required for proper axonal guidance during early brain development and involved in N&
    • 8208;methyl&
    8208; d&
    8208;aspartate&
    8208;mediated synaptic transmission
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC4 interact with the presynaptic ligands netrin-G2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTTL2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS