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FLASH GENE

Symbol

NTNG2

contributors: mct - updated : 04-12-2019

HGNC name	netrin G2
HGNC id	14288

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	80.89 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032536 8 - 3113 NP_115925 - 530 - 2011 21946559

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     predominantly Homo sapiens Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	22 laminin EGF-like domains
	5 laminin g-like domains
	one laminin IV domain
	one laminin n-terminal domain
	the alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure

conjugated

GlycoP

HOMOLOGY

intraspecies

paralog to NTNG1

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	extracellular matrix

basic FUNCTION	may be mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
	implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
	plays a role in synapse formation and maintenance
	both the GNG2 and the NTNG2 proteins show an affinity to the claustrum and related formations in the human brain
	NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
	pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties
	membrane-anchored protein implicated in the molecular organization of neuronal circuitry and synaptic organization
	required for proper axonal guidance during early brain development and involved in N&
	8208;methyl&
	8208; d&
	8208;aspartate&
	8208;mediated synaptic transmission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

LRRC4 interact with the presynaptic ligands netrin-G2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RTTL2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS