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FLASH GENE
Symbol NTNG2 contributors: mct - updated : 04-12-2019
HGNC name netrin G2
HGNC id 14288
Corresponding disease
RTTL2 Rett-like syndrome 2
Location 9q34.13      Physical location : 135.037.333 - 135.118.220
Synonym name
  • laminet 2
  • netrin G1
  • bA479K20.1 (novel protein)
    • Synonym symbol(s) Lmnt2, NTNG1, KIAA1857, MGC21884, bA479K20.1, KIAA0625, LHLL9381, MGC21884
    DNA
    TYPE functioning gene
    STRUCTURE 80.89 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3113 - 530 - 2011 21946559
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  predominantly Homo sapiens
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 22 laminin EGF-like domains
  • 5 laminin g-like domains
  • one laminin IV domain
  • one laminin n-terminal domain
  • the alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure
    • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to NTNG1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text extracellular matrix
    basic FUNCTION
  • may be mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • implicated in the pathophysiology of schizophrenia and bipolar disorder (Eastwood 2008)
  • plays a role in synapse formation and maintenance
  • both the GNG2 and the NTNG2 proteins show an affinity to the claustrum and related formations in the human brain
  • NTGN1/LRRC4C, NTGN2/LRRC4 interactions differentially control synaptic plasticity in distinct circuits via retrograde signaling mechanisms
  • pre-synaptic NTNG1 and NTNG2 diversify the complexity of vertebrate behaviors and differentially regulate post-synaptic properties
  • membrane-anchored protein implicated in the molecular organization of neuronal circuitry and synaptic organization
  • required for proper axonal guidance during early brain development and involved in N&
    • 8208;methyl&
    8208; d&
    8208;aspartate&
    8208;mediated synaptic transmission
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC4 interact with the presynaptic ligands netrin-G2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTTL2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS