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FLASH GENE
Symbol ISYNA1 contributors: mct - updated : 05-10-2013
HGNC name inositol-3-phosphate synthase 1
HGNC id 29821
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , trimer
HOMOLOGY
interspecies ortholog to murine Isyna1
Homologene
FAMILY
  • Myo-inositol-1-phosphate synthase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in phospholipid biosynthesis, myo-inositol biosynthesis
  • catalyzes the conversion of glucose-6-phoshate to myo-inositol-1-phosphate
  • catalyzes the synthesis of myo-inositol in cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GAPDH (delivers heme to ISYNA1 through a process that is regulated by its S-nitrosylation)
    • cell & other
  • putative target for mood-stabilizing drugs such as lithium and valproate
    • REGULATION
    activated by its expression can be activated exclusively by the activator and chromatin remodelers, suggesting a dispensable role of histone acetylases in ISYNA1 induction
    Other is regulated, in part, by DNA methylation and significant alterations in methylation patterns during development could have a major impact on inositol phosphate synthase expression in later life
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    spina bifida
    Susceptibility
    Variant & Polymorphism other 1029A>G and maternal glucose <4.5 protecting against spina-bifida
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS