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FLASH GENE
Symbol ISYNA1 contributors: mct - updated : 05-10-2013
HGNC name inositol-3-phosphate synthase 1
HGNC id 29821
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiensFetal
Nervousbrain   highly Homo sapiens
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , trimer
HOMOLOGY
interspecies ortholog to murine Isyna1
Homologene
FAMILY
  • Myo-inositol-1-phosphate synthase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in phospholipid biosynthesis, myo-inositol biosynthesis
  • catalyzes the conversion of glucose-6-phoshate to myo-inositol-1-phosphate
  • catalyzes the synthesis of myo-inositol in cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GAPDH (delivers heme to ISYNA1 through a process that is regulated by its S-nitrosylation)
    • cell & other
  • putative target for mood-stabilizing drugs such as lithium and valproate
    • REGULATION
    activated by its expression can be activated exclusively by the activator and chromatin remodelers, suggesting a dispensable role of histone acetylases in ISYNA1 induction
    Other is regulated, in part, by DNA methylation and significant alterations in methylation patterns during development could have a major impact on inositol phosphate synthase expression in later life
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    spina bifida
    Susceptibility
    Variant & Polymorphism other 1029A>G and maternal glucose <4.5 protecting against spina-bifida
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS