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FLASH GENE
Symbol NFAM1 contributors: - updated : 23-06-2004
HGNC name NFAT activation molecule 1
HGNC id 29872
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine  moderately
Lymphoid/Immunespleen   highly
Respiratorylung   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one immunoglobulin-like V-type domain
  • one ITAM domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be functioning in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters
  • modulating B cell signaling through its ITAM, which regulates B cell development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS