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FLASH GENE
Symbol COLEC11 contributors: mct - updated : 08-10-2011
HGNC name collectin sub-family member 11
HGNC id 17213
Corresponding disease
3MCC 3MC syndrome, COLEC11 related
Location 2p25.3      Physical location : 3.642.636 - 3.692.045
Synonym symbol(s) MGC3279, UNQ596/PRO1182, CL-11, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, CLK1
DNA
TYPE functioning gene
STRUCTURE 49.41 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1320 28 271 - 2006 17179669
8 - 1399 29 268 - 2006 17179669
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivefemale systemovary  highly Homo sapiens
 female systembreastmammary gland highly Homo sapiens
 female systemplacenta  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
Digestivehepatocyte Homo sapiens
DigestivePaneth Homo sapiens
Nervousneuron Homo sapiens
Respiratoryepithelial cell Homo sapiens
Urinarymesangial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a collagen-like domain
  • a carbohydrate recognition domain, thought to have a role in host defense
  • HOMOLOGY
    interspecies ortholog to murine Colec11
    Homologene
    FAMILY protein family of C-type lectins
    CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • sugar binding activity
  • may play a role in innate immunity as a member of the collectin family
  • potentially playing a role in activation of the complement system and in the defense against invading microorganisms
  • serves as a guidance cue for migrating neural crest cells and other cell types during embryogenesis
  • likely behaves as a chemoattractant molecule with effects on migrating neural crest cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    lectin activation pathway, secreted proteins with diverse functions that, as we have shown here, include the orchestration of cell migration during vertebrate embryogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) 3MCC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS