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FLASH GENE
Symbol CNKSR3 contributors: mct - updated : 10-10-2015
HGNC name CNKSR family member 3 connector enhancer of kinase suppressor of ras 3
HGNC id 23034
Location 6q25.2      Physical location : 154.726.433 - 154.831.753
Synonym name
  • membrane associated guanylate kinase interacting protein-like 1
  • connector enhancer of KSR 3
  • maguin-like protein
  • membrane associated guanylate kinase interacting protein-like 1
  • Synonym symbol(s) FLJ31349, MAGI1, CNK3
    DNA
    TYPE functioning gene
    STRUCTURE 105.32 kb     13 Exon(s)
    regulatory sequence Promoter
    Binding site   hormone
    text structure
  • CNKSR3 promoter exhibits two functional aldosterone-responsive regions
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 3 variants encoding the same isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 3277 61 555 - Tzolovsky
    - splicing 3240 61 555 - Tzolovsky
    - splicing 3070 61 555 - Tzolovsky
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    Urinarykidneytubulecollecting duct highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ/DHR/GLGF domain motif
  • sterile alpha motif SAM
  • HOMOLOGY
    interspecies ortholog to murine Magi1
    Homologene
    FAMILY
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in intracellular signaling cascade
  • homologue of scaffold proteins involved in MAPK pathway regulation, and is a direct target of mineralocorticoid receptor (MR) required for the maintenance of transepithelial sodium transport in the kidney
  • CNKSR3 and IPCEF1 produce a single protein that is required for HGF dependent ARF6 activation and migration
  • CNK3 coordinates the dynamic assembly of the SCNN1-regulatory-complex, and promotes context-appropriate aldosterone signal transduction in the regulation of epithelial Na(+) transport
  • is likely a molecular scaffold, which coordinates the assembly of a multiprotein SCNN1-regulatory complex and hence plays a central role in Na(+) homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ILK interacts with the regulatory region of the CNKSR3 gene chromatin to negatively modulate its expression
  • CNKSR3 physically interacts with SCNN1A, B, D, NEDD4L, and SGK1 and stimulates SCNN1A, SCNN1B, SCNN1D function in a PDZ domain-dependent, aldosterone-induced manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS