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FLASH GENE

Symbol

TXNDC6

contributors: - updated : 20-02-2006

HGNC name	thioredoxin domain containing 6
HGNC id	21343

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q22.3      Physical location : 137.980.278 - 138.048.728
Synonym symbol(s)	TXL-2

DNA

TYPE	functioning gene
STRUCTURE	68.00 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Txl-2 - splicing - 36 330 - Sadek et al. delta-5 Txl-2 - splicing - - 291 - Sadek et al. lacking exon 5

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system male genital tract seminiferous tubule

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid Respiratory epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal thioredoxin domain
	a C-terminal nucleoside diphosphate kinase (NDK) domain

mono polymer

homomer , monomer , dimer

HOMOLOGY

Homologene

FAMILY

thioredoxin and NDK, group II, families

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	may be a regulator of microtubule physiology
	catalyzes conversion of nucleosides diphosphate to nucleosides triphosphate (UTP, CTP, GTP)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS