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FLASH GENE
Symbol RPE contributors: - updated : 04-01-2007
HGNC name ribulose-5-phosphate-3-epimerase
HGNC id 10293
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 3'-5' exonuclease domain
  • a HRDC domain
    • HOMOLOGY
    Homologene
    FAMILY ribulose-phosphate 3-epimerase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in nonsense-mediated decay of mRNAs containing premature stop codons
  • required for the 3' processing of the 7s pre-RNA to the mature 5.8s rRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the nuclear exosome 3'->5' exoribonuclease complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS