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FLASH GENE
Symbol RPE contributors: - updated : 04-01-2007
HGNC name ribulose-5-phosphate-3-epimerase
HGNC id 10293
Location 2q32-q33.3      Physical location : 210.867.351 - 210.886.289
Synonym symbol(s) MGC2636, RPE2-1
EC.number 5.1.3.1
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked N status confirmed
Physical map
CRYGB 2q33-q35 crystallin, gamma B CRYGA 2q33-q35 crystallin, gamma A LOC389073 2 similar to RIKEN cDNA D630023F18 LOC130429 2q34 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) IDH1 2q32-qter isocitrate dehydrogenase 1 (NADP+), soluble PIP5K3 2q34 phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III LOC391478 2 similar to ARP2/3 complex 41 kDa subunit (P41-ARC) (Actin-related protein 2/3 complex subunit 1B) PTHR2 2q33 parathyroid hormone receptor 2 LOC130195 2q34 similar to Heat shock cognate 71 kDa protein LOC391479 2 similar to Chain  , Heat-Shock Cognate 70 Kd Protein (44 Kd Atpase N-Terminal Fragment) (E.C.3.6.1.3) Mutant With Thr 204 Replaced By Val (T204v) LOC389074 LOC391480 2 similar to PKP4 protein MAP2 2q34 microtubule-associated protein 2 FLJ33496 SNAI1L1 2q34 snail homolog 1 like 1 (Drosophila) RPE 2q32-q33.3 ribulose-5-phosphate-3-epimerase FLJ23861 2q34 hypothetical protein FLJ23861 ACADL 2q34 acyl-Coenzyme A dehydrogenase, long chain MYL1 2q34 myosin, light polypeptide 1, alkali; skeletal, fast LANCL1 2q33-q35 LanC lantibiotic synthetase component C-like 1 (bacterial) CPS1 2q35 carbamoyl-phosphate synthetase 1, mitochondrial PRO0132 2q34 PRO0132 protein ERBB4 2q34 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2492 - 228 - Krull
- - 2130 - 178 - Krull
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineneuroendocrinepituitary  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 3'-5' exonuclease domain
  • a HRDC domain
  • HOMOLOGY
    Homologene
    FAMILY ribulose-phosphate 3-epimerase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in nonsense-mediated decay of mRNAs containing premature stop codons
  • required for the 3' processing of the 7s pre-RNA to the mature 5.8s rRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the nuclear exosome 3'->5' exoribonuclease complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS