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FLASH GENE

Symbol

RPE

contributors: - updated : 04-01-2007

HGNC name	ribulose-5-phosphate-3-epimerase
HGNC id	10293

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q32-q33.3      Physical location : 210.867.351 - 210.886.289
Synonym symbol(s)	MGC2636, RPE2-1
EC.number	5.1.3.1

DNA

TYPE	functioning gene
STRUCTURE	19.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 2492 - 228 - Krull V2 - - 2130 - 178 - Krull

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine neuroendocrine pituitary     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 3'-5' exonuclease domain
	a HRDC domain

HOMOLOGY

Homologene

FAMILY

ribulose-phosphate 3-epimerase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in nonsense-mediated decay of mRNAs containing premature stop codons
	required for the 3' processing of the 7s pre-RNA to the mature 5.8s rRNA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the nuclear exosome 3'->5' exoribonuclease complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS