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FLASH GENE
Symbol CEP78 contributors: mct - updated : 19-10-2016
HGNC name centrosomal protein 78kDa
HGNC id 25740
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-rich repeat (LRR) region, which is composed of 20–29 AA sequence motifs that are present in many proteins that participate in protein-protein interactions and have different functions and cellular locations
    • HOMOLOGY
    interspecies homolog to rattus Ip63
    homolog to murine Cep78
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • mainly a centriolar protein that localizes to the centriolar wall
    • basic FUNCTION
  • may be involved in cell shape, polarity, motility and in cell division
  • is required for PLK4-induced centriole overduplication
  • ciliary protein, that might function as a tumor suppressor
    • CELLULAR PROCESS cell cycle
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with another centrosomal protein, C-Nap1, encoded by CEP250
  • centrosomal protein and a new interaction partner of PLK4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORDHL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer cells significantly reduced cell viability and colony formation and halted tumor growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serve as a novel prognostic marker in Colorectal cancer
    • Therapy target
    ANIMAL & CELL MODELS