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FLASH GENE
Symbol CEP78 contributors: mct - updated : 19-10-2016
HGNC name centrosomal protein 78kDa
HGNC id 25740
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-rich repeat (LRR) region, which is composed of 20–29 AA sequence motifs that are present in many proteins that participate in protein-protein interactions and have different functions and cellular locations
    • HOMOLOGY
    interspecies homolog to rattus Ip63
    homolog to murine Cep78
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • mainly a centriolar protein that localizes to the centriolar wall
    • basic FUNCTION
  • may be involved in cell shape, polarity, motility and in cell division
  • is required for PLK4-induced centriole overduplication
  • ciliary protein, that might function as a tumor suppressor
    • CELLULAR PROCESS cell cycle
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with another centrosomal protein, C-Nap1, encoded by CEP250
  • centrosomal protein and a new interaction partner of PLK4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CORDHL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer cells significantly reduced cell viability and colony formation and halted tumor growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serve as a novel prognostic marker in Colorectal cancer
    • Therapy target
    ANIMAL & CELL MODELS